• If the patient s coronary artery is very close to

  2019-06-05

  

  If the patient’s coronary artery is very close to the ablation target site, or if the origin of the VT/VPCs cannot be estimated by only the 12-lead ECG, for example, because of a severely deformed thorax or an alteration in the morphology of the VT, the CartoSound® system can be a useful tool for as

• Importance of heart failure Acute

  2019-06-05

  

  Importance of ack1 inhibitor failure Acute decompensated heart failure (ADHF) refers to a clinical condition of worsening HF with dyspnea, often with evidence of fluid overload [1]. This is generally triggered by 1 of the 4 main factors: atrial fibrillation, anemia, hypertension, and medication/di

• When the subject of climate change is raised

  2019-06-01

  

  When the subject of climate change is raised, people tend to think of extreme heat events, droughts, violent storms, rising sea levels, and floods. Today, we certainly live in an era of severe weather events, which will intensify if human-driven climate change continues unabated. Such events are kno

• The data also revealed notable differences

  2019-06-01

  

  The data also revealed notable differences in practice patterns across the countries. In France, Italy, Spain and the UK, patients were most likely to have multiple disseminated sites of metastases at the time of initial bone ppar antagonist detection; however, patients in Germany were most likely t

• Infectious and parasitic diseases cause about half the anaem

  2019-06-01

  

  Infectious and parasitic diseases cause about half the anaemia burden. Stevens and colleagues estimate that iron-amenable anaemia was about 50% in non-pregnant and pregnant women, and 42% in children in 2011. In addition to the contributions of malaria, schistosomiasis, hookworm infection, and HIV,

• The findings of Peck and colleagues are in major ways

  2019-06-01

  

  The findings of Peck and colleagues are in major ways expected and apply to many developing countries. However, the quest for solutions must integrate many other important questions. To what extent is the report by Peck and colleagues specific for NCDs and not only a reflection of an overall non-opt

• Detailed data were available in Kilifi

  2019-06-01

  

  Detailed data were available in Kilifi not only on carriage of vaccine types of pneumococci, but also on receipt of vaccine by the individuals in the study, and the overall vaccine coverage in the ap1 was also known. The data suggest that vaccine coverage of around two-thirds of children younger th

• br Acknowledgements br Introduction The chronic myeloprolife

  2019-06-01

  

  Acknowledgements Introduction The chronic myeloproliferative neoplasms (MPN) comprise a group of clonal stem cell disorders with a high prevalence of the JAK2 V617F mutation (JAK2+) causing excessive production of mature blood cells. Transformation to acute myeloid leukemia (AML) is seen in 2–

• While it has been reported that the combination

  2019-06-01

  

  While it has been reported that the combination therapy of As2O3 and ATRA is highly effective not only as the front-line treatment [6], but also in relapsed and treatment-refractory APL patients [7], showing fewer adverse events than the combination of ATRA and chemotherapeutic drugs, the efficacy a

• The multivariable analyses by Keats and colleagues identifie

  2019-06-01

  

  The multivariable analyses by Keats and colleagues identified factors associated with higher coverage of key interventions in Kenya. Current and prospective efforts tracking key indicators and their determinants over time could enable time-series regression and more sophisticated causal inference an

• purchase KU-60019 Understanding and defining these miRNA pro

  2019-06-01

  

  Understanding and defining these miRNA profiles helps to uncover the clinical usefulness of miRNAs. Numerous human clinical trials are currently evaluating miRNA therapeutics during various liver diseases, such as targeting miR-122 during chronic hepatitis C infection. Aside from therapeutics, the d

• br Primary biliary cholangitis Primary biliary cholangitis P

  2019-05-31

  

  Primary biliary cholangitis Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is another rare but devastating immune-mediated cholangiopathy. Similar to PSC, PBC is characterized by portal inflammation leading to fibrosis and eventually cirrhosis. Distinct from PSC

• The Cochrane review on exercise after lung resection identif

  2019-05-31

  

  The Cochrane review on exercise after lung resection identified three randomized trials involving 178 participants. The meta-analysis found that exercise capacity was statistically greater in the exercise training group compared to the control group following lung resection for NSCLC. No between-gro

• br Authorship br Conflict of interest disclosure br Introduc

  2019-05-30

  

  Authorship Conflict of interest disclosure Introduction The Aurora kinases are serine/threonine protein kinases essential for regulation of normal dhpg mitosis. Aurora kinases A (AAK) and B are overexpressed in hematologic malignancies, including acute myeloid leukemia (AML) and myelodyspla

• 4EGI-1 Introduction Researchers have long followed the strat

  2019-05-30

  

  Introduction Researchers have long followed the strategy that in order to achieve a fuller understanding of the causes of disease and how they can be prevented, it is necessary to study the biochemical and physiological processes involved in the etiology of disease. As I have argued in previous pap

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