• In this study we conducted allozyme analyses to test

  2020-07-30

  

  In this study, we conducted allozyme analyses to test the hypothesis that these intermediate plants are of hybrid origin. We focus on the following two questions: (1) Are the two groups of intermediate plants of hybrid origin?, (2) What are the genetic relationships among these Nuphar taxa? Mater

• In the proposed language a concrete architectural model cons

  2020-07-30

  

  In the proposed language, a concrete architectural model consists of a set of individual components (ConcreteComponent) and a set of relationships (Relationship) among them. Each component has a type, defined by ComponentType. The container component type identifies a component that contains other c

• An Accelerated Degradation Test ADT is the method used

  2020-07-30

  

  An Accelerated Degradation Test (ADT) is the method used to analyze (2). ADT extends the QALT technique. Rather than looking at failure times, ADT uses degradation measures to produce a time to failure. ADT fits well for aging-related failures as these are particularly difficult to empirically obser

• Here we discuss implications of several major

  2020-07-29

  

  Here, we discuss implications of several major families of RING-type E3 ubiquitin ligases (MDM, Cullin, GRAIL, TRAF, TRIM) as targets in inflammation and immunity, and provide insights into potential small molecule interventions to mediate the cellular responses (summarized in Table 1). We briefly c

• Medaka Oryzias latipes is used as a useful model

  2020-07-29

  

  Medaka (Oryzias latipes) is used as a useful model in radiation biology [10], [11]. RIC1 strain was isolated as a radiation-sensitive mutant strain of Medaka via N-ethyl-N-nitrosourea ENU-mutagenesis screening [12]. Previously, we established four RIC1 cell lines from each single embryo and reported

• BYL719 In some fish a rise in plasma progesterone P levels

  2020-07-29

  

  In some fish a rise in plasma progesterone (P4) levels and changes of mPR abundance in gonads were reported to be associated with oocyte maturation and ovulation (Kagawa et al., 1981, Kazeto et al., 2005b) and sperm mobility is also regulated by non-genomic progesterone actions in fish and mammals (

• br Result and discussion br Conclusions In this paper

  2020-07-28

  

  Result and discussion Conclusions In this paper we introduced a new generation of hDHODH inhibitors designed by scaffold hopping replacement of the acidic moiety of brequinar with different hydroxylated azoles. All the designed compounds can potently inhibit hDHODH in vitro, reaching an IC50 v

• Understanding the nature of protein collagen interactions

  2020-07-28

  

  Understanding the nature of protein–collagen interactions is also crucial in developing biomaterials that replicate the structural and biological characteristics of collagen [140]. These biomaterials can then be applied to develop scaffolds or tissues that can be valuable in surgeries or medicine [7

• In a recent study Tomkins et

  2020-07-28

  

  In a recent study, Tomkins et al. [7] analyzed the protein-protein interaction network of ROCO proteins. Based on a database analysis, and only taking into account interactions reported in at least two peer-reviewed papers and/or confirmed by two different methods, 113 interactors were revealed for

• Guinea pigs have been used as experimental animals for

  2020-07-28

  

  Guinea pigs have been used as experimental animals for the development of LT modifiers, because their airway smooth muscles respond well to CysLTs. In guinea pigs, CysLT2 receptors are mainly activated by LTC4, whereas LTD4 is known to potently activate CysLT1 receptors (Ito et al., 2008). In humans

• br Materials and methods br Results br

  2020-07-28

  

  Materials and methods Results Discussion In the present study, we found that CysLTs (LTD4 and LTC4) induced expression and release of the pro-inflammatory cytokine IL-8 by activating the CysLT2 receptor. Our results further indicate that the effect is mainly mediated through the ERK1/2-Egr-

• RF 9 mg Acknowledgments br PGD is an arachadonic acid derive

  2020-07-28

  

  Acknowledgments PGD is an arachadonic acid-derived prostaglandin produced in large quantities when asthmatic lung tissues are challenged by allergens. PGD contracts the airway tissue as well as stimulating an inflammatory response. PGD was also found to be the ligand for a second receptor, DP2 (

• In this modeling approach first the cross

  2020-07-28

  

  In this modeling approach, first, the cross-association volume parameter of the various mixtures of water + hydrocarbon was optimized as the only adjusting parameter of the model. Previous studies showed [59], [60] aromatics can form weak hydrogen bonds with alcohols and water, but there is not enou

• Here we report the cloning expression and characterization o

  2020-07-28

  

  Here we report the cloning, expression and characterization of two CK1 isoforms of T. gondii and describe their sensitivity to a collection of structurally diverse CDK inhibitors. As predicted from earlier affinity-ligand purification studies [11], we have confirmed the sensitivity of one of these i

• Cholesterol Chol metabolism consists of a

  2020-07-28

  

  Cholesterol (Chol) metabolism consists of a complex set of interactive input and output fluxes with the aim to provide the large membrane bound Chol pool with sufficient Chol molecules. For this purpose, two input fluxes are active. One is the Cyclo of dietary Chol, the other is de novo Chol synthes

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