• Our observation that FAK is

  2020-08-28

  

  Our observation that FAK is downregulated in vascular smooth muscle DY131 on fibrillar collagen confirms observations reported for other cell types [14]. However, unlike the results reported previously [14], our work suggests that matrix rigidity per se does not determine FAK downregulation. This c

• G DH has gained interest

  2020-08-27

  

  G3DH has gained interest because of its broad substrate specificity and site-selective oxidation properties [9,10]. The conversion product, 3-ketoglycoside, possesses potential as a starting material for the chemical industry such as in polymer and surfactants because the keto group becomes a specif

• br Materials and methods F philippinensis plants

  2020-08-26

  

  Materials and methods F. philippinensis plants were collected in August 2014 at a farm in Ninning, Guangxi province, China and identified by Dr. Yimmin Zhao. Voucher specimens (No. 530) were deposited in the Herbarium of Gaunxi Botanical Garden, China. Human recombinant neutrophil elastase (EC 3.

• br Lymphoplasmacytic lymphoma Waldenstrom macroglobulinemia

  2020-08-26

  

  Lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia Lymphoplasmacytic lymphoma (LPL) and its subgroup Waldenstrom macroglobulinemia (WM) are rare and indolent lymphomas that arise from fully differentiated B cells. The only family of GPCRs that has been well studied in LPL/WM is the chemokin

• Only a few studies have examined the effect of prostanoids

  2020-08-26

  

  Only a few studies have examined the effect of prostanoids on cardiac fibroblasts. Therefore, this study examines the effect of PGE2 on cardiac fibroblast proliferation and tests the hypothesis that PGE2 causes cardiac fibroblast proliferation via alterations of Kifunensine regulatory molecules and

• The majority of serpins inhibit serine

  2020-08-26

  

  The majority of serpins inhibit serine proteases, but serpins that inhibit caspases or papain-like cysteine proteases have also been identified [4], [5]. Inhibitory serpins are ‘suicide’ or ‘single use’ inhibitors that use a unique conformational change to inhibit proteases. This conformational tran

• br Conclusions When the authors joined the field of

  2020-08-26

  

  Conclusions When the authors joined the field of oxysterol analysis around the turn of the century, oxysterols and cholestenoic acids were mostly considered as uninteresting intermediates of cholesterol metabolism. Some oxysterols had been shown to have biological activity, but the most studied o

• To investigate the mechanism of action of trisubstituted azo

  2020-08-24

  

  To investigate the mechanism of action of 2,4,5-trisubstituted azoles, we profiled selected 2,4,5-trisubstituted azoles against a panel of 97 kinases to identify potential targets that could be involved in cardiogenesis. We narrowed down the identified targets to the casein kinase 1 (CK1) family due

• Molecular docking study of compound was performed using the

  2020-08-24

  

  Molecular docking study of Galanthamine HBr was performed using the Schrödinger Small-Molecule Drug Discovery Suite taking advantage of known X-ray crystal structures of activated EPAC2 protein. The model shows that compound occupies the CBD of EPAC2 and forms hydrogen bonds with Arg448 and the cyan

• Our results demonstrate that pt PGE in addition to

  2020-08-24

  

  Our results demonstrate that 17-pt-PGE2 - in addition to its described effects on EP1 and EP3 receptors - also acts as an EP4 agonist and thereby enhances vascular barrier function. Materials and methods Results Discussion In this study we demonstrate that the purported EP1/EP3 receptor ag

• Enolase as a plasminogen receptor and activator

  2020-08-24

  

  Enolase, as a plasminogen receptor and activator localized on the surface of several helminths, can interact with the host fibrinolytic system (Yang et al., 2010, Du et al., 2009, de la Torre-Escudero et al., 2010). The enzyme is also one of excretory/secretory (ES) products in some helminths, such

• In pregnancy maternal uterine spiral artery SA remodeling is

  2020-08-24

  

  In pregnancy, maternal uterine spiral artery (SA) remodeling is essential for ensuring efficient blood flow to the developing fetus. A subset of CD49a+Eomes+ decidual NK MRS 2179 tetrasodium salt (dNK) that actively secretes GFs, such as pleiotrophin and osteoglycin, have recently been described in

• In conclusion we propose that UBE T FANCT

  2020-08-24

  

  In conclusion, we propose that UBE2T (FANCT) mutations define a FA subtype. This is also a rare example of a mutated E2 enzyme causing an inherited human disorder, like UBE2A. The p.Gln2Glu substitution is probably hypomorphic, as indicated by the fact that a siUBE2T knockdown made AP65P-hTERT dcp c

• Increased levels of PCNA monoubiquitination by UbL P express

  2020-08-24

  

  Increased levels of PCNA monoubiquitination by UbL73P expression in a damage-independent manner mimics the phenotype observed for USP1 knockdown (Huang et al., 2006, Jones et al., 2012). USP1 is the only DUB to date shown to remove ubiquitin from PCNA in vivo. This finding reveals the highly dynamic

• Consistent with a clear separation of

  2020-08-24

  

  Consistent with a clear separation of biological function between ARISC and BRISC in cells, mutations in BRCC36 and Abraxas are prevalent in cancer genomes whereas mutations in KIAA0157 are rare. A survey of the Catalogue of Somatic Mutations in Cancer (COSMIC) consortium, revealed that to date, 37

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