• In the present study we

  2021-04-17

  

  In the present study, we found that the up-regulatory effects of androgens on ep1 transcripts might be mediated by Arα in the olfactory rosette of B. sinensis. However, in mammals, there is no evidence of AR expression in either the vomeronasal organ or the sensory epithelium of main olfactory epith

• Our knowledge of DDR induced

  2021-04-17

  

  Our knowledge of DDR-induced signaling pathways is still fragmentary. In particular, we do not know which signaling effectors interact with the phosphorylated receptors and how different effectors are linked to the control of specific cellular functions. The DDRs are at the interface between RTKs an

• Diabetic retinopathy is a chronic inflammatory disease

  2021-04-17

  

  Diabetic retinopathy is a chronic inflammatory disease. Local inflammation plays a pivotal role in the pathological development and progression of this disease [24]. In addition to TNF-α, several other cytokines, chemokines, and other factors such as IL-1β, IL-6, and C-reactive protein have been ind

• Introduction Amphetamine AMPH methamphetamine MA and

  2021-04-17

  

  Introduction Amphetamine (AMPH), methamphetamine (MA), and 3,4-ethylenedioxymethamphetamine (MDMA) are widely abused psychoactive substances, with the basic chemical structure of phenylethylamine [1]. The abuse of these drugs is associated with psychostimulant, anorectic and hallucinogenic properti

• br Materials and methods br Results br Discussion

  2021-04-17

  

  Materials and methods Results Discussion In this study, we developed a new CysLT1 and CysLT2 receptors-mediated Sulfasalazine guinea pig model for screening both CysLT2 receptor and CysLT1/2 receptor antagonists. Unlike human CysLT2 receptors, which are equally stimulated by both LTC4 and

• br Acknowledgements br Introduction Chemokines are a

  2021-04-17

  

  Acknowledgements Introduction Chemokines are a superfamily of chemotactic cytokines that play important roles in regulating cell migration and activation under inflammatory conditions (Nomiyama et al., 2008; Peatman and Liu, 2007; Zlotnik and Yoshie, 2000), such as angiogenesis (Arenberg et al

• br Making the BN Cox

  2021-04-16

  

  Making the BN-Cox model computationally efficient One of the challenges to applying the BN-Cox model is an exponential growth of the conditional probability tables (CPT) corresponding to the survival variables, as the number of risk factors increases [22]. When the number of risk factors is high,

• On top of the hardware ASTS employs Linux SUSE with

  2021-04-16

  

  On top of the hardware, ASTS employs Linux SUSE with High-Availability (HA) Extension: a COTS OS provided with two clustering software (Pacemaker Cluster Resource Manager (CRM) and Corosync) responsible for resources orchestration, failure diagnosis, nodes coordination, and fail-over management. The

• Co operation or synergy between PKA and

  2021-04-16

  

  Co-operation or synergy between PKA and Epac has been recently reported in PCCL3 thyroid cell line in which cAMP is pro-mitogenic, in MK-8669 to VSMC [19]. Our study demonstrates for the first time that PKA and Epac also synergise to inhibit cell proliferation in a cell type where cAMP in anti-mito

• cetylpyridinium br Activatable MRI probes MRI is commonly us

  2021-04-16

  

  Activatable MRI probes MRI is commonly used in clinics around the world and has the advantages of outstanding tissue-penetration depth and extremely high spatial resolution for in vivo imaging [33]. MRI has relatively poor sensitivity and usually requires cetylpyridinium agents to enhance the ima

• 7ACC1 sale OxLDL down regulates eNOS and up regulates iNOS

  2021-04-16

  

  OxLDL down-regulates eNOS and up-regulates iNOS, thereby augmenting the formation of NO and protein S-nitrosylation in human endothelial 7ACC1 sale [26]. Importantly, iNOS-mediated S-nitrosylation plays an increasingly significant role in cardiovascular diseases [34]. For example, iNOS-mediated IRE1

• br Introduction Increasing investigations show

  2021-04-16

  

  Introduction Increasing investigations show that the earthworm extract has various beneficial pharmacological activities, including fibrinolytic [2] and anticoagulative activity [3], anti-inflammatory activity [4], anti-oxidative activity [5], [6], peripheral nerve regeneration [7], bone regenera

• WES and validation by Sanger sequencing in

  2021-04-16

  

  WES and validation by Sanger sequencing in PNGS-252 revealed an apparent homozygous c.4C>G missense alteration (GenBank: NM_014176.3), resulting in the amino Albendazole substitution p.Gln2Glu (Figure 1A). This mutation must be very rare, because this is not listed in the NHLBI Exome Sequencing Pro

• Structural changes within the heteromer induced

  2021-04-16

  

  Structural changes within the heteromer induced by agonist administration show a high level of complication. The presented results obtained in quantitative FLIM-FRET measurements with two selective ligands match the qualitative conclusions indicated by changes in the intracellular calcium level. The

• br Discussion The biochemical separation

  2021-04-16

  

  Discussion The biochemical separation of exonuclease activity from DNA-PK dependent endonuclease activity reported in this manuscript is consistent with genetic separation of Artemis enzymatic activity. Mutations in the protein which result in disruption of endonuclease activity have no effect on

15833 records 676/1056 page Previous Next First page 上5页 676677678679680 下5页 Last page