• Although most of the incretin effects

  2022-07-01

  

  Although most of the incretin effects on aphidicolin receptor metabolism can be secondary to their action on insulin/glucagon secretion, some evidence strongly suggests that they could also act directly on liver glucose utilization and production [4], [13], [22], [27], [34], [44]. Supporting this co

• br Vertebrate steroid receptor evolution br Conclusion The t

  2022-07-01

  

  Vertebrate steroid receptor evolution Conclusion The teleost WGD event resulted in the duplication of the vertebrate GR and MR and two GRs have been retained in the majority of teleost fish studied so far. The molecular basis for this retention has yet to be fully understood. The cloning of th

• One major mode of bioelectric

  2022-07-01

  

  (2) One major mode of bioelectric action is that of an amplifier of subcellular symmetry-breaking mechanisms into tissue-wide order. An example is the patterning of the embryonic left (L)-right (R) axis reviewed in References [57, 58]; the following scheme describes the data obtained largely from th

• Cellular inhibition is caused by the

  2022-06-30

  

  Cellular inhibition is caused by the hyperpolarization of the cell and is mediated by both synaptic and extrasynaptic GABAARs. Synaptic GABAARs are sensitive to high concentrations of GABA released at the synapse and mediate phasic inhibition. In contrast, extrasynaptic GABAARs mediate tonic inhibit

• Angiotensin I (human, mouse, rat) A frequent complication of

  2022-06-30

  

  A frequent complication of SIRS and sepsis is the development of increased airway resistance and lung inflammation [2], [3]. For example, Uhlig et al. [3] demonstrated that rat lungs exposed to endotoxin present increased airway resistance due to constriction of terminal Angiotensin I (human, mouse,

• Ro 48-8071 br Discussion The initial reduction

  2022-06-30

  

  Discussion The initial reduction and the subsequent increase in permeability proposes a regulatory process to control bleeding. However, following repeated injury, or during long-term presence of the inflammatory stimuli, these mechanisms may become defective and even detrimental. The expression

• SCH 527123 Chicoric acid CA is a di

  2022-06-30

  

  Chicoric SCH 527123 (CA) is a di-acylated hydroxycinnamoyl tartaric acid ester [12] found in a variety of plant species, especially within the Astereceae family [13]. Of interest for this study, Sonchus oleraceus and Bidens pilosa plants, from Astereceae family, were used. Both S. oleraceus and B. p

• br Introduction Ovarian cancer patients have the highest mor

  2022-06-30

  

  Introduction Ovarian cancer patients have the highest mortality rate amongst patients with gynecologic cancers. The 10-year survival rate of ovarian cancer patients is cancer Doxorubicin with BRCA1/2 mutation [2]. Several studies have indicated the role of dysregulation of histone methylation i

• In NAFLD models the first

  2022-06-30

  

  In NAFLD models, the “first hit” is liver fat accumulation, which causes insulin resistance, whereas the interplay of inflammatory cytokines, which causes inflammation, acts as the representative “second hit” [9]. However, recently, the “multiple hit” hypothesis has taken into consideration that mul

• br Conflict of interest br Funding br Introduction

  2022-06-30

  

  Conflict of interest Funding Introduction Heme is an essential molecule for cellular metabolism involving oxygen and electron transfer [1]. However, free heme is a potent pro-oxidant that catalyzes the generation of reactive oxygen species (ROS) leading to cellular damage [2]. Heme oxygenas

• SJB3-019A synthesis Considering that loss of LAG expression

  2022-06-29

  

  Considering that loss of LAG-3 SJB3-019A synthesis results in increased CD4+ T cell homeostatic expansion, and that the ability of a cell to proliferate is tightly coupled to its metabolic profile, we hypothesized that LAG-3 regulates naive CD4+ T cell metabolism. Our results indicate that, indeed,

• The advent of next generation sequencing NGS has

  2022-06-29

  

  The advent of next-generation sequencing (NGS) has shown that considerable variation in human genome is still undiscovered and therefore a considerable number of rare variations that are related to disease susceptibility may still be unknown. NGS has allowed to strengthen the association between los

• Glutamate is a ubiquitous principal excitatory neurotransmit

  2022-06-29

  

  Glutamate is a ubiquitous principal excitatory neurotransmitter in the urotensin ii that plays a central role in a variety of brain functions (Delgado, 2013, Hawkins, 2009). Several studies reported that CSF glutamate was associated with mental illness, including major depressive disorder, anxious a

• br Regulation of Glu transporters The pivotal role

  2022-06-29

  

  Regulation of Glu transporters The pivotal role of Glu transporters in the fine tuning and turnover of this excitatory amino thiostrepton calls for a detailed characterization of its regulation. Several general mechanisms that modify Glu uptake activity have been described. These include transcri

• GLI proteins activate or repress transcription

  2022-06-29

  

  GLI proteins activate or repress transcription of their target genes by binding to a similar sequence motif within a cis-regulatory module (CRM) (Hallikas and Taipale, 2006, Peterson et al., 2012). Transcriptional responses to the HH pathway can be elicited either by de-repression of GLI-R or in oth

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