• In contrast to short term

  2022-09-28

  

  In contrast to short-term effects, long-term exposure of beta cells to FFAs impairs insulin secretion and triggers apoptosis [13]. The deleterious effects of FFAs have been linked to altered glucose/fatty gssg oxidation cycle [13], decreased NADPH content [14], endoplasmic reticulum (ER) stress [15

• Increasing evidence has shown that blockade

  2022-09-28

  

  Increasing evidence has shown that blockade of glutamate uptake leads to aberrant behavioral consequences. For example, intracerebroventricular (i.c.v) injection or microinjection of the GLT-1 inhibitor, dihydrokainic Ceftazidime (DHK), into the prefrontal cortex induces anhedonia [8,9]. Microinjec

• Throughout the last few decades

  2022-09-28

  

  Throughout the last few decades, evidence has accumulated indicating that NTTs, whose primary location is the cell surface, are subject to a series of regulatory processes of intracellular traffic to and from the membrane (Robinson and Jackson, 2016; Vaughan and Foster, 2013). In addition, lateral m

• br Introduction Glucose is the major carbon source in

  2022-09-28

  

  Introduction Glucose is the major carbon source in most organisms. Cancer FPH1 sale in particular require a steady source of energy to maintain growth and proliferation, and preferentially use glycolysis for their energy supply even under aerobic conditions. Glucose uptake in mammals is mainly m

• To support maximal growth and metabolic

  2022-09-28

  

  To support maximal growth and metabolic function of major organs, glucose and LB42708 are essential. We assessed the plasma levels of glucose and amino acids in LBW and NBW piglets at birth and at day 7 postpartum. Blood glucose levels were influenced by birthweight and age. In this study, the leve

• A key limiting factor in the

  2022-09-28

  

  A key limiting factor in the semi-quantitative analysis of changes in the nuclear-to-cytoplasmic distribution of glucokinase is the large intercellular heterogeneity of Syringin of glucokinase in both isolated hepatocytes in vitro and also in liver in vivo[13], [23], [24], [26], [36]. This necessita

• This work was supported by the

  2022-09-28

  

  This work was supported by the National Natural Science Foundation of China (Grants 81471101 and 81870852), the Natural Science Foundation of Jiangsu Province (Grant BK20181146), the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (Grants 18KJA320007 and 17KJB320018)

• meclofenamate N Cadherin facilitated gap junction formation

  2022-09-28

  

  N-Cadherin facilitated gap junction formation between embryonic lens meclofenamate by stabilizing membrane appositions (Frenzel and Johnson, 1996). Cx43 has been found to be delivered to N-Cadherin-positive membrane HeLa cells (Shaw et al., 2007), and N-Cadherin determine the localization of Cx43 in

• Cys loop GABA receptors are

  2022-09-27

  

  Cys-loop GABA receptors are well-studied targets for insecticides and also play an important role in nematode biology. These receptors are also targets for the anthelmintic piperizine (Accardi et al., 2012). The nematode GABA receptor most studied is the UNC-49 receptor which plays a role in muscle

• br Acknowledgements We apologize to our

  2022-09-27

  

  Acknowledgements We apologize to our distinguished colleagues whose work has not been cited owing to space limitations. This work was funded by the Italian Association for Cancer Research (AIRC, Milan, Italy, IG 14732 to A.M.); Italian Ministry of University and Education (Finanziamenti per la Ri

• The suboptimal trypsin selectivity profile of DPC p

  2022-09-26

  

  The suboptimal trypsin selectivity profile of DPC423 prompted us to investigate additional P moieties for potency and selectivity. Glycinamide P () showed low nanomolar binding affinity against fXa which suggested that this P moiety sits deeper into the S pocket of fXa. To further elaborate on this

• Over decades a deeper understanding of terpene synthases

  2022-09-26

  

  Over decades, a deeper understanding of terpene synthases has also permitted enzyme engineering for unnatural substrate acceptance. Novel terpenoids have been successfully synthesized from substrate analogues as by-products from mechanistic investigation (Faraldos et al., 2012; Miller, Yu, & Alleman

• A large body of literature have reported that various cellul

  2022-09-24

  

  A large body of literature have reported that various cellular pathways are dysregulated in NPC [19]. Among these pathways, Akt is frequently hyperactivated in NPC and regulates diverse cellular processes including tumor cell growth, proliferation, metabolism, survival and invasion, as well as angio

• Another important outcome of reducing hypothalamic HIF

  2022-09-24

  

  Another important outcome of reducing hypothalamic HIF in DIO was the increase in gliosis and hypothalamic inflammation. Both experimental and human studies have shown that hypothalamic inflammation plays an important role in obesity by inducing resistance to anorexigenic signals, such as insulin an

• Firstly the impact on activity and

  2022-09-22

  

  Firstly, the impact on activity and selectivity was made by replacing the 2, 3-di-F substitution of ring A with 2,3-OCHO- () and 2-NO () substitutions, and replacing the 3, 5-di-F substitution of ring B with 3,5-di-OMe () and 3,5-di-Me () substitutions. Compound kept moderate activity (EC = 220 nM)

15188 records 341/1013 page Previous Next First page 上5页 341342343344345 下5页 Last page