• The main consequence of glucose catabolism is the

  2022-10-08

  

  The main consequence of glucose catabolism is the elevation of ATP concentration, which in turn suppresses the ATP sensitive potassium (KATP) channels gating function. The KATP channels are octamers composed of the tetrameric inward-rectifying potassium channels (with Kir6.1 and Kir6.2 subunits), th

• Hh signaling pathway plays an

  2022-10-04

  

  Hh signaling pathway plays an essential role in the regulation of invertebrate and vertebrate tissue development and metabolic homeostasis. Components of Hh signaling pathway have been identified in succession, including Hh ligands, membrane protein receptors, cytoplasmic components and transcriptio

• br Trifluoromethylketones This group of compounds was demons

  2022-10-04

  

  Trifluoromethylketones This group of compounds was demonstrated to bind the zinc Nile Red in the active site due to its easy hydration, forming the required chelating intermediate. Ontaria et al. [92] have proposed variations around the cap group of trifluoromethylthiophene as the core motif for

• isoquercitrin The haspin gene is also unusual because

  2022-10-04

  

  The haspin gene is also unusual because it lacks introns. This is more remarkable when one compares the mammalian genes to those of likely haspin orthologs that are present in the genomic sequences of other species. Such genes in Drosophilamelagonaster, Arabidopsisthaliana and Caenorhabditiselegans

• vegf inhibitor The neotropical fish Prochilodus lineatus has

  2022-10-04

  

  The neotropical fish Prochilodus lineatus has been widely used in experimental designs for being sensitive to variations in water quality and tolerant to laboratory conditions (Camargo and Martinez, 2006, Cazenave et al., 2014, da Silva and Martinez, 2014, Vieira et al., 2016). Concern and reports a

• Recently a G protein coupled receptor

  2022-10-04

  

  Recently, a G-protein-coupled receptor, GPR109a, was identified as a molecular target for niacin. Mechanistic studies have suggested that the benefits of niacin therapy may result from the activation of GPR109a located on adipocytes. Recent experiments have shown that niacin activation of GPR109a re

• There was a statistical significant correlation between CD

  2022-10-04

  

  There was a statistical significant correlation between CD39 expression on CD4+ T cells and CD38 and ZAP-70 (Table 3). Del 6q was detected in 19 patients (63.3%) with a range of 2–75% and a mean of 32.97 ± 14.85. As regards to the staging system, del 6q was significantly higher in high risk group o

• Cytarabine Based on our finding that TFA

  2022-10-04

  

  Based on our finding that TFA modulates GlyR function and reports that TFA-bound Cytarabine can differ markedly from those synthesized without TFA, we retested a previously published dodecapeptide (D12-116) that also enhanced GlyR function but this time as a chloride salt (Tipps et al., 2010). No d

• br Acknowledgements This research was

  2022-10-04

  

  Acknowledgements This research was funded by Ministry of Education Malaysia (MOE), and supported by the Department of Nutrition, Exercise & Sports, Department of Drug Design, University of Copenhagen, Denmark and Universiti Malaysia Pahang (UMP), Malaysia. HPLC equipment used for high-resolution

• When we compared the effects in FST induced by

  2022-10-02

  

  When we compared the effects in FST induced by GAL and GAL(1–15), we observed that the increase in the immobility induced by GAL(1–15) was significantly higher than the one induced by GAL (Millon et al., 2015). Moreover, in climbing behaviour, GAL(1–15) also induced a stronger decrease in climbing r

• Type II diabetes is characterized by an inability to maintai

  2022-10-02

  

  Type II diabetes is characterized by an inability to maintain glucose homeostasis due to insulin desensitization and/or insufficient insulin secretion. GPR40, also known as free fatty WIN 64338 hydrochloride receptor 1 (FFAR1), is a member of the G-protein-coupled lipid-activated family of receptors

• CTGF is an established YAP TAZ

  2022-10-02

  

  CTGF is an established YAP/TAZ target gene which plays a central role in tissue remodeling. Downregulation of CTGF mediates collagen loss in chronologically-aged human skin whereas persistent activation of CTGF can result in excessive deposition of collagen and fibrotic disorders [63]. The authors f

• A few animal and cell

  2022-10-01

  

  A few animal and cell culture studies have been reported that the reason of HCV-related hepatic steatosis in CHC infection is mainly HCV core protein (Chang et al., 2007; Perlemuter et al., 2002; Ferré, 2004). HCV core protein inhibits activities of microsomal triglyceride transfer protein (MTP) and

• In addition to changes in the Rho

  2022-10-01

  

  In addition to changes in the Rho isoforms, all Rac isoforms, including the constitutively active splice variant of Rac1, Rac1b, are overexpressed in various tumors and accumulating evidence indicates that they play an important role in the metastatic potential of cancer hydroxychloroquine sulfate

• br GSNOR regulates SA synthesis and SA signalling

  2022-10-01

  

  GSNOR1 regulates SA synthesis and SA signalling The phenolic metabolite salicylic wdr5 synthesis (SA) is a powerful immune activator in plants. Moreover, mutations that disable SA biosynthesis or transgenes that result in its depletion compromise both resistance (R) gene-mediated and basal resist

15188 records 339/1013 page Previous Next First page 上5页 336337338339340 下5页 Last page