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br Acknowledgements br Introduction Diabetic complications a
2023-08-26
Acknowledgements Introduction Diabetic complications are responsible for increased morbidity and mortality of diabetic patients. Increased flow of Iodoacetyl-LC-Biotin through the polyol pathway under conditions of hyperglycemia contributes to the development of diabetic complications. Aldose
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Corticosterone induced inhibition of OCT
2023-08-26
Corticosterone-induced inhibition of OCT-mediated transport is rapid and appears to involve direct interaction of the steroid with the transporter at a specific site. Volk et al. (2003) studied OCT2-mediated transport by measuring substrate-induced currents using patch clamp of Xenopus oocytes exoge
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br Methods br Results br Discussion br Acknowledgements
2023-08-25
Methods Results Discussion Acknowledgements This work was supported by the National Institutes of Health [Grant R21 NS081429], a Pilot Grant from the Vanderbilt Conte Center supported by the National Institutes of Health [Grant P50 M096972], and by the Department of Anesthesiology at V
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Active SI behavior was dose dependently
2023-08-25
Active SI behavior was dose-dependently affected by PACAP treatment (F3,25 = 14.42, p rat (Figure 2D). Treatment with PACAP affected osi sc 175 1 week later (F3,20 = 8.93, p hypothesis that PACAP causes disruptions in posterror adjustments that are similar to disruptions seen in humans with depress
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It is worth mentioning that cordycepin as an adenosine analo
2023-08-25
It is worth mentioning that cordycepin, as an adenosine analogue, is structurally similar to adenosine. A previous study has shown that the anti-apoptotic effects of cordycepin are partially dependent on the activation of A1R [16], and cordycepin increases theta waves power density via nonspecific a
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salubrinal australia Considering the physicochemical stabili
2023-08-25
Considering the physicochemical stability results on Fig. 5, it was observed that the particles are stable when they are stored at 4 °C for 30 days. After day 30, a significant increase was observed in particle size, but at the end of the 90 days the SLN particle size is still below 100 nm. Stabilit
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br Materials and methods br Results br Discussion
2023-08-25
Materials and methods Results Discussion The success of CAR-T cell therapy is based on two major facts: one is that cancer cells express tumor-associated antigens (TAAs) on their surface that can be detected by the human immune system; the other is that the CAR molecules target these TAAs o
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The first description of autophagy as
2023-08-25
The first description of autophagy as a tumour suppression process arises from the observation that the initial step regulatory gene, Atg6/BECN1, was monoallelically lost in 40% to 75% of human prostate, breast, and ovarian cancers [31]. However, while BECN1 heterozygous mutant mice develop, with lo
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Introduction Antimicrobial resistance is a growing health th
2023-08-25
Introduction Antimicrobial resistance is a growing health threat worldwide that has been associated with incorrect prescription and overuse of NVP-AEE788 australia [1]. Considering that physicians play a central role in antibiotic usage, a better understanding of their prescribing behaviours and t
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Aconitase clusters are prone to oxidations
2023-08-25
Aconitase clusters are prone to oxidations and are among the first to undergo a change in transition state during stages of electrophilic stress rendering them inactive [31]. Aconitase activity in LETO and OLETF did not differ at T0 suggesting that the early onset of insulin resistance may not be at
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Recent retrospective cohort studies have
2023-08-25
Recent retrospective cohort studies have supported these preclinical findings in animals indicating the correlation of AR activation with the induction of Fmoc-L-Arg(Aloc)2-OH carcinogenesis. First, men with prostate cancer who underwent androgen deprivation therapy were shown to have a significant
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br Acknowledgments br Introduction Amyloid deposit formation
2023-08-25
Acknowledgments Introduction Amyloid deposit formation is defined by the aggregation of β-sheeted forms of proteins that appear as starch-like amorphous material [1], [2]. Using a Kongo red stain, amyloids show birefringence behavior and an apple-green to reddish multicolor emission. Extracere
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A has been reported to decrease
2023-08-25
Aβ has been reported to decrease insulin receptors and impair insulin signaling in neurons, preventing phosphorylation of Akt and glycogen synthase kinase 3β (GSK-3β), downstream of insulin signaling, and to increase phosphorylation of tau protein causing neurofibrillary tangles (Tokutake et al., 20
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Similar to Cys Met can undergo ROS
2023-08-25
Similar to Cys, Met can undergo ROS-mediated oxidation to Met sulfoxide, which can result in changes in protein conformation and activity [43]. In our results, the Met content in wild ginseng is higher compared to cultivated ginseng (1.3 times, Table 1). Met is a substrate for the synthesis of vario
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br Impact of global AHR deficiency on diet induced obesity
2023-08-25
Impact of global AHR deficiency on diet-induced obesity Two subsequent studies in which AHR function was affected at the whole animal level corroborated the role of AHR in dietary obesity. Xu et al. [14] showed that on a high-fat diet, both AHR-deficient Ahr−/− and hemizygous Ahr+/− mice gained s
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