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br MADS box proteins in plants a
2023-10-26
MADS box proteins in plants, a flourishing family In contrast to animals, homeotic genes in plants do not code for homeodomain-containing proteins, but rather, in almost all cases, for MADS domain proteins. The sequencing of the genome of Arabidopsis thaliana revealed more than 100 putative MADS
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Since the first studies of betaine
2023-10-26
Since the first studies of betaine aldehyde oxidation in rats [13], the participation of betaine in the detoxification of homocysteine has well described, considering the activity of other SCH 39166 hydrobromide receptor as betaine homocysteine methyltransferase and methionine synthase. But, there i
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br ABCA is a sterol responsive gene The first evidence
2023-10-26
ABCA2 is a sterol-responsive gene The first evidence to demonstrate that ABCA2 expression responded to sterol loading was provided in an experiment involving monocyte to macrophage differentiation in vitro. Upon sterol loading with enzymatically degraded LDL (eLDL), ABCA2 expression increased onl
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It is worth mentioning that cordycepin as an
2023-10-26
It is worth mentioning that cordycepin, as an adenosine analogue, is structurally similar to adenosine. A previous study has shown that the anti-apoptotic effects of cordycepin are partially dependent on the activation of A1R [16], and cordycepin increases theta waves power density via nonspecific a
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br Expression of ADK in the normal brain In
2023-10-26
Expression of ADK in the normal brain In adult brain, ADK is primarily expressed in astrocytes. Immunocytochemical analysis of adult rat and mouse DiscoveryProbe™ Inhibitor Library revealed predominant astrocytic expression throughout the hippocampus and cortex. Two isoforms of ADK have been ide
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br Funding br Introduction l Dihydroxyphenylalanine l DOPA i
2023-10-26
Funding Introduction l-3,4-Dihydroxyphenylalanine (l-DOPA) is the gold-standard treatment for the motor symptoms of Parkinson's disease (PD); however, its chronic use induces severe motor complications that eventually limit its long-term efficacy (Bastide et al., 2015). The most disabling side
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LO is a soluble kDa
2023-10-26
5-LO is a soluble 78 kDa enzyme, composed of an α-helix-rich catalytic domain and a regulatory β-sheet-rich C2-like domain. Depending on the cell type, 5-LO may be located in the cytosol, in the nucleoplasm, or in both compartments (Werz, 2002). Upon cell stimulation by agents that elevate intracell
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The benzimidazole group seems to
2023-10-26
The benzimidazole group seems to be a key feature for the excellent anti-tumor activity of galeterone (159), which motivated the synthesis of new steroidal inhibitors containing N-heterocyclic groups structurally related to benzimidazole. Thus, several 1H- and 2H-indazole derivatives of dehydroepian
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According to the present observations the Ampk
2023-10-25
According to the present observations, the Ampkα1 isoform promotes AP-1 transcriptional activity and thereby fosters β(1,3)-d-glucan synthase of AP-1 target genes in cardiomyocytes via activation of Pkcζ. The transcription factor AP-1 plays a decisive role during cardiac remodeling [24], [25], [26]
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Although sex hormones activational effects are known
2023-10-25
Although sex hormones (activational effects) are known to directly interact with RAS (Baiardi et al., 2005, Miller et al., 1999, Silbiger and Neugarten, 1995), the potential contribution of organizational hormonal and SCC effects on physiological sex-based difference in the regulation of the RAS rem
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fura 2 receptor Recent retrospective cohort studies have sup
2023-10-25
Recent retrospective cohort studies have supported these preclinical findings in animals indicating the correlation of AR activation with the induction of fura 2 receptor carcinogenesis. First, men with prostate cancer who underwent androgen deprivation therapy were shown to have a significantly low
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Our observation that squalestatin caused only small differen
2023-10-25
Our observation that squalestatin caused only small differences in the production of Aβ40 and Aβ42 was in contrast to prior reports of the effects of other cholesterol synthesis inhibitors. This may be due to using squalestatin, a more specific cholesterol synthesis inhibitor that does not affect is
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Tropomyosi http www apexbt com media diy images wb B
2023-10-25
Tropomyosin-related kinases (Trks) play crucial role in neurotrophin-mediated cellular activities, including neuronal differentiation, survival, and synaptic function [37] through activating downstream signaling mediators PI3K and Akt [38]. In a therapeutic context, Akt has been shown to mediate str
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To investigate the potential link
2023-10-25
To investigate the potential link between Gβγ and MT assembly in vivo, cultured NIH3T3 and PC12 cells were used. The role of Gβγ in MT assembly was demonstrated using nocodazole, a MT depolymerizing drug [14]. We found that Gβγ was preferentially bound to MTs in NIH3T3 and PC12 cells and treatment w
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Since forskolin is known to
2023-10-25
Since forskolin is known to act directly at the catalytic site of adenylate cyclases near the ATP binding (Tesmer et al., 1997), the synergistic and/or permissive effect of gonadotropins on FSK activity must occur at the level of AC itself or very near, at the level of one of its direct partner. The
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